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北京大学生命科学学院

本站2019-07-0249人围观
简介 个人简介科研领域代表性论文本实验室主要兴趣在于: 利用X-射线晶体学手段及其它物理、化学、遗传学技术研究生物学和临床医学的基本问题;特别是研究物质代谢系统,蛋白质体内合成系统,以及与细胞凋亡

北京大学生命科学学院

个人简介科研领域代表性论文本实验室主要兴趣在于:  利用X-射线晶体学手段及其它物理、化学、遗传学技术研究生物学和临床医学的基本问题;特别是研究物质代谢系统,蛋白质体内合成系统,以及与细胞凋亡和肿瘤的信号传导机制相关的蛋白质结构。   基于结构的蛋白质工程及药物(蛋白和小分子药物)设计方法。   利用常规及同步辐射X光源研究结构生物学方法,特别是单波长异常散射方法和低分辨率从头定相位方法;  利用和开发不同宿主系统来表达,纯化那些重要且难于制备的蛋白分子,特别是用于结构和功能研究的糖蛋白,膜蛋白等。

  利用生化及物理学手段研究大分子相互作用及识别机理,特别是功能大分子复合物,细胞黏附,以及它们在神经系统发育,癌症发生及转移中的作用功能    ,LanfenLi,Xiao-DongSu*,“StructuralandbiochemicalcharacterizationofMdaBfromStreptococcusmutansrevealsaNADPH-specificquinoneoxidoreductase”,ActaCrystallogrSectDStructBiol.,2014,70(Pt4):,Xiao-JunWang,Lan-fenLiandXiao-DongSu*,“Theregulatorymechanismofcaspase-6pro-domainrevealedbycrystalstructureandbiochemicalassays”,ActaCrystallogrSectDStructBiol.,2014,70(Pt1):,ChenHM,YangMY,ZhangCB,YuK,YeWL,HuBQ,YanW,ZhangW,AkersJ,RamakrishnanV,LiJ,CarterB,LiuYW,HuHM,WangZ,LiMY,YaoK,QiuXG,KangCS,YouYP,FanXL,LiRQ,SuXD,ChenCC,JiangT.,“RNA-Seqof272gliomasrevealedanovel,recurrentPTPRZ-METfusiontranscriptinsecondaryglioblastomas”GenomeResearch,GenomeResearch,2014,(accepted),Jian-shi;Lian,Teng-fei;Xie,Xiaoliang,Xiao-DongSu*,“Singlemoleculestudiesoftheinteractionbetweenthenucleosomalglucocorticoidresponseelementandtheglucocorticoidreceptor”,&,2014,(accepted),QinCao,YanZhangandXiao-DongSu*,“ActivationandRegulationofCaspase-6andItsRoleinNeurodegenerativeDiseases”,,2014,(accepted),LanfenLi,Xiao-DongSu*,StructureofhumanCLOCK-BMAL1bHLHdomainsandDNAcomplexprovidesinsightsintoprotein-protein/DNArecognitionandtranscriptioncontrol,CellRes.,2013,23(2):,LanfenLi,Xiao-DongSu*,Structuralandbiochemicalanalysisofanovalα/β,Proteins.,2013,82(4):695-700doi:/,BrostrmerE,XingD,JinJ,ChongS,GeH,WangS,GuC,YangL,GaoYQ,SuXD*,SunY*,XieXS*.,ProbingallosterythroughDNA.”,Science.,2013,339(6121):,ZhangH,GaoZQ,WangWJ,SheZ,LiuGF,ShenYQ,SuXD*,DongYH*,“StructuralinsightsintotheinhibitionoftypeVIeffectorTae3byitsimmunityproteinTai3.”,BiochemJ,2013,454(1)::/,ZhangH,GaoZQ,WangWJ,LiuGF,XuJH,SuXD*,DongYH*.,StructureofthetypeVIeffector-immunitycomplex(Tae4-Tai4)providesnovelinsightsintotheinhibitionmechanismoftheeffectorbyitsimmunityprotein.,JBiolChem.,2013,288(8):,ZhuoM,SuZ,DuanJ,GaoY,WangZ,ZongC,BaiH,ChapmanA,ZhaoJ,XuL,AnT,MaQ,WangY,WuM,SunY,WangS,LiZ,YangX,YongJ,SuXD,LuY,BaiF*,XieXS*,andWangJ*,“ReproducibleCopyNumberVariationPatternsamongSingleCirculatingTumorCellsofLungCancePatients”,,PNAS110(2013),2013,,JieNan,Yu-HeLiang,PengMao,LuLu,LuhuaLai,YiLi,andXiao-DongSu,DNABindingMechanismRevealedbyHighResolutionCrystalStructureofArabidopsisthalianaWRKY1Protein,Nucleicacidresearch,2012,35(4):,JieNan,Yu-HeLiang,PengMao,LuLu,LuhuaLai,YiLi,andXiao-DongSu,DNABindingMechanismRevealedbyHighResolutionCrystalStructureofArabidopsisthalianaWRKY1Protein,Nucleicacidresearch,2012,35(4):,,Anautomatedimage-collectionsystemforcrystallizationexperimentsusingSBSstandardmicroplates,ActaCrystallogrDBiolCrystallogr,2007,63:,,Anautomatedimage-collectionsystemforcrystallizationexperimentsusingSBSstandardmicroplates,ActaCrystallogrDBiolCrystallogr,2007,63:,LiangY,LiL,NanJ,BrostromerE,LiuP,DongY,XianD,Alarge-scale,high-efficiencyandlow-costplatformforstructuralgenomicsstudies,ActaCrystallogrDBiolCrystallogr,2006,62(8):,LiangYH,BrostromerE,QuanJM,PanjikarS,DongYH,SuXD,AcatalyticmechanismrevealedbythecrystalstructuresoftheimidazolonepropionasefromBacillussubtilis,,2006,281(48):,LiangY,LiL,NanJ,BrostromerE,LiuP,DongY,XianD,Alarge-scale,high-efficiencyandlow-costplatformforstructuralgenomicsstudies,ActaCrystallogrDBiolCrystallogr,2006,62(8):,LiangYH,BrostromerE,QuanJM,PanjikarS,DongYH,SuXD,AcatalyticmechanismrevealedbythecrystalstructuresoftheimidazolonepropionasefromBacillussubtilis,,2006,281(48):,LiyaWang,MatthewBennett,YuheLiang,XiaofengZheng,FeiLu,LanfenLi,JieNan,MingLuo,StaffanEriksson,ChuanmaoZhang,andXiao-DongSu,TheCrystalStructureofhumanAdenylateKinase6:AnAdenylateKinaseLocalizedtotheCellNucleus,(PNAS),2005,102:,YuheLiang,MagnusAbrahamsonandXiao-DongSu,CrystalstructureofhumancystatinD,acysteinepeptidaseinhibitorwithrestrictedinhibitionprofile,,2005,280:,LiyaWang,MatthewBennett,YuheLiang,XiaofengZheng,FeiLu,LanfenLi,JieNan,MingLuo,StaffanEriksson,ChuanmaoZhang,andXiao-DongSu,TheCrystalStructureofhumanAdenylateKinase6:AnAdenylateKinaseLocalizedtotheCellNucleus,(PNAS),2005,102:,YuheLiang,MagnusAbrahamsonandXiao-DongSu,CrystalstructureofhumancystatinD,acysteinepeptidaseinhibitorwithrestrictedinhibitionprofile,,2005,280:,M.;andSu,X.-D,CrystalstructureofanmRNAbindingfragmentofMoorellathermoaceticaSelB,EMBOJ.,2002,21(15):,M.;andSu,X.-D,CrystalstructureofanmRNAbindingfragmentofMoorellathermoaceticaSelB,EMBOJ.,2002,21(15):,M.;Guan,Z.;,X-D,Bacillussubtilisarsenatereductaseisstructurallyandfunctionallysimilartolowmolecular-weightproteintyrosinephosphatases,(PNAS),2001,98:,M.;Guan,Z.;,X-D,Bacillussubtilisarsenatereductaseisstructurallyandfunctionallysimilartolowmolecular-weightproteintyrosinephosphatases,(PNAS),2001,98:13577-13582。